STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs

被引：53

作者：

Micheau, O ^{[1
]}

Hammann, A ^{[1
]}

Solary, E ^{[1
]}

Dimanche-Boitrel, MT ^{[1
]}

机构：

[1] Fac Med & Pharm, Dept Biol & Therapy Canc JE515, NSERM U517, F-21033 Dijon, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 256卷 / 03期

关键词：

anticancer drugs; FAS; FADD; caspases; apoptosis;

D O I：

10.1006/bbrc.1999.0391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously shown that treatment by anticancer drugs sensitized tumor cells to Fas (APO-1/CD95)-mediated cell death. The present study demonstrates that the cytotoxic drugs cisplatin, doxorubicin and mitomycin C induce the accumulation of the Fas receptor, the FADD adaptor molecule, the procaspases-8, -3 and -2L and the proapoptotic molecule Bar in several human colon cancer cells. This upregulation is also observed in U3A myeloblastoma cells that do not express STAT-1, a transcription factor involved in the constitutive expression of procaspases. We conclude that anticancer drugs sensitize tumor cells to Fas-mediated cell death by a STAT-1-independent upregulation of molecules involved in this apoptotic pathway, (C) 1999 Academic Press.

引用

页码：603 / 607

页数：5

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