Variants associated with common disease are not unusually differentiated in frequency across populations

被引:39
作者
Lohmueller, KE
Mauney, MM
Reich, D
Braverman, JM
机构
[1] Georgetown Univ, Dept Biol, Washington, DC 20057 USA
[2] Georgetown Univ, Dept Comp Sci, Washington, DC 20057 USA
[3] Georgetown Univ, Inst Mol & Human Genet, Med Ctr, Washington, DC 20057 USA
[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA
[5] MIT, Cambridge, MA 02139 USA
[6] Harvard Univ, Broad Inst, Cambridge, MA 02138 USA
关键词
D O I
10.1086/499287
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Genetic variants that contribute to risk of common disease may differ in frequency across populations more than random variants in the genome do, perhaps because they have been exposed to population-specific natural selection. To assess this hypothesis empirically, we analyzed data from two groups of single-nucleotide polymorphisms ( SNPs) that have shown reproducible (n = 9) or reported (n = 39) associations with common diseases. We compared the frequency differentiation ( between Europeans and Africans) of the disease-associated SNPs with that of random SNPs in the genome. These common-disease-associated SNPs are not significantly more differentiated across populations than random SNPs. Thus, for the data examined here, ethnicity will not be a good predictor of genotype at many common-disease-associated SNPs, just as it is rarely a good predictor of genotype at random SNPs in the genome.
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收藏
页码:130 / 136
页数:7
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