Amphiphilic star copolymers containing cyclodextrin core and their application as nanocarrier

被引：61

作者：

Adeli, Mohsen ^{[1
,2
]}

Zarnegar, Zohre ^{[1
]}

Kabiri, Roya ^{[3
]}

机构：

[1] Lorestan Univ, Fac Sci, Dept Chem, Khorramabad, Iran

[2] Lorestan Univ, Nanotechnol Ctr, Khorramabad, Iran

[3] Tabriz Univ, Lab NMR, Tabriz, Iran

来源：

EUROPEAN POLYMER JOURNAL | 2008年 / 44卷 / 07期

关键词：

host-guest; poly(2-ethyl-2-oxazoline); poly(lactide); (beta-cyclodextrin; amphiphilic copolymers;

D O I：

10.1016/j.eurpolymj.2008.03.028

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Amphiphilic copolymers containing beta-cyclodextrin (beta-CD) core were synthesized successfully. Synthesis was initiated from tosylated cyclodextrin ((Tosyl)(7)-beta-CD) which is containing two types of functional groups. Hydroxyl functional groups of (Tosyl)(7)-beta-CD were used as initiator for ring opening polymerization of lactide. This step led to star polymers containing tosylated cyclodextrin core and polylactide arms (PLA-(Tosyl)(7)-beta-CD). In the next step, tosyl groups of PLA-(Tosyl)(7)-beta-CD were used as initiator for ring opening polymerization of 2-ethyl-2-oxazoline and amphiphilic copolymers containing cyclodextrin core, PLA and poly(2-ethyl-2-oxazoline) arms (PLA-beta-CD-POX) were obtained. Loading of Congo red as guest molecule by amphiphilic copolymers was investigated. The release of guest molecule from chloroform solution of copolymers to water phase was also investigated. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1921 / 1930

页数：10

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