The wear of metal-on-metal bearings is affected by various design parameters, Such as the clearance or Surface roughness. It Would be very useful to have a significant indicator of wear according to these design parameters, such as the Lambda ratio. Three different batches of cast high- and low-carbon cobalt-chromium hip implants (28 mm, 32 mm, and 36 mm diameters) were tested in a hip joint simulator for 2 x 1.0(6) cycles. Bovine calf serum was used as lubricant, and the samples were weighed at regular intervals during the test. The predictive role of the Lambda ratio on the wear behaviour was investigated. Three different configurations were tested to explore the wear rate for a broad range of Lambda ratios. The results of these studies clearly showed that the femoral heads of 36 mm diameter had the best wear behaviour with respect to the other two smaller configurations tested. From a predictive point of view, the Lambda ratios associated with the configurations tested Could clearly indicate that the femoral heads of 36 mm diameter worked in the mixed-lubrication regime (Lambda > 1); all the smallest configurations (28 mm size) had Lambda < 1, thus showing their aptitude to work in the boundary lubrication regime, with substantially higher volume depletion due to wear. The Lambda values associated with the 32 mm size varied in a range around 1 (0.95 < Lambda < 1.16), Suggesting the possibility of operating in the mixed-lubrication regime.