OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group

被引：57

作者：

Gossec, Laure ^{[1
,2
]}

Paternotte, Simon ^{[1
,2
]}

Bingham, Clifton O., III ^{[3
,4
]}

Clegg, Daniel O. ^{[5
]}

Coste, Philippe ^{[6
]}

Conaghan, Philip G. ^{[7
,8
]}

Davis, Aileen M. ^{[9
,10
,11
]}

Giacovelli, Giampaolo ^{[12
]}

Gunther, Klaus-Peter ^{[13
]}

Hawker, Gillian ^{[14
,15
]}

Hochberg, Marc C. ^{[16
,17
]}

Jordan, Joanne M. ^{[18
]}

Katz, Jeffrey N. ^{[19
,20
,21
]}

Kloppenburg, Margreet ^{[22
]}

Lanzarotti, Arturo ^{[23
]}

Lim, Keith ^{[24
,25
]}

Lohmander, L. Stefan ^{[26
]}

Mahomed, Nizar N. ^{[27
]}

Maillefert, Jean Francis ^{[28
,29
,30
]}

Manno, Rebecca L. ^{[3
]}

March, Lyn M. ^{[31
]}

Mazzuca, Steven A. ^{[32
]}

Pavelka, Karel ^{[33
]}

Punzi, Leonardo ^{[34
]}

Roos, Ewa M. ^{[35
]}

Rovati, Lucio C.

Shi, Helen ^{[36
]}

Singh, Jasvinder A. ^{[37
,38
]}

Suarez-Almazor, Maria E. ^{[39
]}

Tajana-Messi, Eleonora ^{[23
]}

Dougados, Maxime ^{[1
,2
]}

机构：

[1] Paris Descartes Univ, Fac Med, Paris, France

[2] Cochin Hosp, AP HP, Rheumatol Dept B, Paris, France

[3] Johns Hopkins Univ, Div Rheumatol, Baltimore, MD USA

[4] Johns Hopkins Univ, Div Clin Immunol & Allergy, Baltimore, MD USA

[5] Univ Utah, Sch Med, Dept Internal Med, Div Rheumatol, Salt Lake City, UT USA

[6] Expansci Labs, Courbevoie, France

[7] Univ Leeds, Sect Musculoskeletal Dis, Leeds, W Yorkshire, England

[8] NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

[9] Univ Toronto, Div Hlth Care & Outcomes Res, Toronto, ON, Canada

[10] Univ Toronto, Toronto Western Res Inst, Arthrit & Community Res & Evaluat Unit, Toronto, ON, Canada

[11] Univ Toronto, Dept Rehabil Sci, Toronto, ON, Canada

[12] Rottapharm Madaus, Dept Clin Pharmacol, Dept Biostat, Monza, Italy

[13] Univ Dresden, Dept Orthopaed Surg, Dresden, Germany

[14] Univ Toronto, Womens Coll Hosp, Div Rheumatol, Dept Med, Toronto, ON M5S 1A1, Canada

[15] Univ Toronto, Fac Med, Dept Hlth Policy Management & Evaluat, Clin Epidemiol & Hlth Care Res Program, Toronto, ON M5S 1A1, Canada

[16] Univ Maryland, Sch Med, Dept Med, Div Clin Immunol & Rheumatol, Baltimore, MD 21201 USA

[17] Univ Maryland, Sch Med, Div Gerontol, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA

[18] Univ N Carolina, Sch Med, Thurston Arthrit Res Ctr, Div Rheumatol Allergy & Immunol,Dept Med, Chapel Hill, NC USA

[19] Harvard Univ, Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Sch Med, Boston, MA 02115 USA

[20] Harvard Univ, Dept Orthoped Surg, Sch Med, Boston, MA 02115 USA

[21] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[22] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Dept Rheumatol, Leiden, Netherlands

[23] IBSA Inst Biochim SA, R&D Dept, Pambio Noranco, Switzerland

[24] St Vincents Hosp, Dept Rheumatol, Melbourne, Vic, Australia

[25] Western Hosp, Melbourne, Vic, Australia

[26] Lund Univ, Dept Orthopaed, Lund, Sweden

[27] Univ Toronto, Toronto Western Hosp, Div Orthopaed Surg, Toronto, ON M5T 2S8, Canada

[28] Dijon Univ Hosp, Dept Rheumatol, Dijon, France

[29] Univ Burgundy, Dijon, France

[30] INSERM, U887, Dijon, France

[31] Univ Sydney, Royal N Shore Hosp, Inst Bone & Joint Res, St Leonards, NSW 2065, Australia

[32] Indiana Univ Sch Med, Indianapolis, IN USA

[33] Charles Univ Prague, Inst Rheumatol, Prague, Czech Republic

[34] Univ Padua, Dept Clin & Expt Med, Rheumatol Unit, Padua, Italy

[35] Univ So Denmark, Inst Sports & Clin Biomech, Odense, Denmark

[36] VA Cooperat Studies Program Coordinating Ctr, Hines, IL USA

[37] Birmingham VA Med Ctr, Birmingham, AL USA

[38] Univ Alabama Birmingham, Birmingham, AL USA

[39] Univ Texas MD Anderson Canc Ctr, Rheumatol Sect, Houston, TX 77030 USA

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 08期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

OSTEOARTHRITIS; SEVERITY; PAIN; FUNCTION; STRUCTURE OUTCOME MEASURE; DOUBLE-BLIND; RADIOGRAPHIC FEATURES; GLUCOSAMINE SULFATE; PHYSICAL-FUNCTION; PROGRESSION; PAIN; ASSOCIATION; 3-YEAR; 2-YEAR; PS;

D O I：

10.3899/jrheum.110403

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective. To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement surgery," for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA). Methods. New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons' indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA. Results. In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%-12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0-100) + physical function (0-100) > 80]. Conclusion. These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define "nonresponders" to disease-modifying drugs in OA clinical trials. (J Rheumatol 2011;38:1765-9; doi:10.3899/jrheum.110403)

引用

页码：1765 / 1769

页数：5

共 25 条

[1]

Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee - Results of the two-year multinational knee osteoarthritis structural arthritis study [J].

Bingham, Clifton O., III ;

Buckland-Wright, J. Chris ;

Garnero, Patrick ;

Cohen, Stanley B. ;

DougadoS, Maxime ;

Adarni, Silvano ;

Clauw, Daniel J. ;

Spector, Timothy D. ;

Pelletier, Jean-Pierre ;

Raynauld, Jean-Pierre ;

Strand, Vibeke ;

Simon, Lee S. ;

Meyer, Joan M. ;

Cline, Gary A. ;

Beary, John F. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (11) :3494-3507

[2]

Effects of doxycycline on progression of osteoarthritis - Results of a randomized, placebo-controlled, double-blind trial [J].

Brandt, KD ;

Mazzuca, SA ;

Katz, BP ;

Lane, KA ;

Buckwalter, KA ;

Yocum, DE ;

Wolfe, F ;

Schnitzer, TJ ;

Moreland, LW ;

Manzi, S ;

Bradley, JD ;

Sharma, L ;

Oddis, CV ;

Hugenberg, ST ;

Heck, LW .

ARTHRITIS AND RHEUMATISM, 2005, 52 (07) :2015-2025

[3]

Association of pain with radiological changes in different compartments and views of the knee joint [J].

Cicuttini, FM ;

Baker, J ;

Hart, DJ ;

Spector, TD .

OSTEOARTHRITIS AND CARTILAGE, 1996, 4 (02) :143-147

[4]

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis [J].

Clegg, DO ;

Reda, DJ ;

Harris, CL ;

Klein, MA ;

O'Dell, JR ;

Hooper, MM ;

Bradley, JD ;

Bingham, CO ;

Weisman, MH ;

Jackson, CG ;

Lane, NE ;

Cush, JJ ;

Moreland, LW ;

Schumacher, HR ;

Oddis, CV ;

Wolfe, F ;

Molitor, JA ;

Yocum, DE ;

Schnitzer, TJ ;

Furst, DE ;

Sawitzke, AD ;

Shi, H ;

Brandt, KD ;

Moskowitz, RW ;

Williams, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (08) :795-808

[5]

The development of a short measure of physical function for hip OA HOOS-Physical Function Shortform (HOOS-PS): an OARSI/OMERACT initiative [J].

Davis, A. M. ;

Perruccio, A. V. ;

Canizares, M. ;

Tennant, A. ;

Hawker, G. A. ;

Conaghan, P. G. ;

Roos, E. M. ;

Jordan, J. M. ;

Maillefert, J. -F. ;

Dougados, M. ;

Lohmander, L. S. .

OSTEOARTHRITIS AND CARTILAGE, 2008, 16 (05) :551-559

[6]

Comparative, validity and responsiveness of the HOOS-PS and KOOS-PS to the WOMAC physical function subscale in total joint replacement for Osteoarthritis [J].

Davis, A. M. ;

Perruccio, A. V. ;

Canizares, M. ;

Hawker, G. A. ;

Roos, E. M. ;

Maillefert, J. -F. ;

Lohmander, L. S. .

OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (07) :843-847

[7]

Variations in the pre-operative status of patients coming to primary hip replacement for osteoarthritis in European orthopaedic centres [J].

Dieppe, Paul ;

Judge, Andrew ;

Williams, Susan ;

Ikwueke, Ifeoma ;

Guenther, Klaus-Peter ;

Floeren, Markus ;

Huber, Joerg ;

Ingvarsson, Thorvaldur ;

Learmonth, Ian ;

Lohmander, L. Stefan ;

Nilsdotter, Anna ;

Puhl, Wofhart ;

Rowley, David ;

Thieler, Robert ;

Dreinhoefer, Karsten .

BMC MUSCULOSKELETAL DISORDERS, 2009, 10

[8]

Dougados M, 2001, ARTHRITIS RHEUM-US, V44, P2539, DOI 10.1002/1529-0131(200111)44:11<2539::AID-ART434>3.0.CO

[9]

2-T

[10]

OARSI/OMERACT Criteria of Being Considered a Candidate for Total Joint Replacement in Knee/Hip Osteoarthritis as an Endpoint in Clinical Trials Evaluating Potential Disease Modifying Osteoarthritic Drugs [J].

Dougados, Maxime ;

Hawker, Gillian ;

Lohmander, Stefan ;

Davis, Aileen M. ;

Dieppe, Paul ;

Maillefert, Jean-Francis ;

Gossec, Laure .

JOURNAL OF RHEUMATOLOGY, 2009, 36 (09) :2097-2099

← 1 2 3 →