CD4+CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response

被引：64

作者：

Fields, ML ^{[1
]}

Hondowicz, BD ^{[1
]}

Metzgar, MH ^{[1
]}

Nish, SA ^{[1
]}

Wharton, GN ^{[1
]}

Picca, CC ^{[1
]}

Caton, AJ ^{[1
]}

Erikson, J ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 175卷 / 07期

关键词：

D O I：

10.4049/jimmunol.175.7.4255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate the mechanism by which T regulatory (Treg) cells may control the early onset of autoimmunity, we have used an adoptive transfer model to track Treg, Th, and anti-chromatin B cell interactions in vivo. We show that anti-chromatin B cells secrete Abs by day 8 in vivo upon provision of undeviated, Th1- or Th2-type CD4(+) T cell help, but this secretion is blocked by the coinjection of CD4(+)CD25(+) Treg cells. Although Treg cells do not interfere with the initial follicular entry or activation of Th or B cells at day 3, ICOS levels on Th cells are decreased. Furthermore, Treg cells must be administered during the initial phases of the Ab response to exert full suppression of autoantibody production. These studies indicate that CD25(+) Treg cells act to inhibit the maturation, rather than the initiation, of autoantibody responses.

引用

页码：4255 / 4264

页数：10

共 57 条

[21]

Jordan MS, 2000, EUR J IMMUNOL, V30, P136, DOI 10.1002/1521-4141(200001)30:1<136::AID-IMMU136>3.0.CO

[22]

2-0

[23] Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide [J].