Conditioned reinstatement of drug-seeking behavior with a discrete compound stimulus classically conditioned with intravenous cocaine

被引:70
作者
Kruzich, PJ [1 ]
Congleton, KM [1 ]
See, RE [1 ]
机构
[1] Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA
关键词
D O I
10.1037//0735-7044.115.5.1086
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The present study investigated the ability of alight and tone (LT) compound stimulus paired with cocaine infusions to reinstate cocaine-seeking behavior, Rats were trained to self-administer cocaine in the Presence or absence of the LT during daily 3-hr sessions (maintenance). During Maintenance Days 5 and 10 rats underwent classical conditioning, whereby passive cocaine infusions were paired with either short-delayed, random, or no presentations of an LT. After extinction sessions. rats underwent test sessions in which the LT was presented in a noncontingent or response-contingent manner to measure Conditioned cocaine-seeking behavior. The results demonstrated that response-contingent LT presentations significantly increased cocaine-seeking behavior and that the LT trained in a classical conditioning format transferred to an operant secondary reinforcer.
引用
收藏
页码:1086 / 1092
页数:7
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