Genetic polymorphism and variability of chemical carcinogenesis

被引：22

作者：

Belitsky, G. A. ^{[1
]}

Yakubovskaya, M. G. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Lab Carcinogen Screening Methods, Blokhin Canc Res Ctr, Moscow 115478, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 05期

关键词：

chemical carcinogenesis; gene polymorphism; cytochrome P450; DNA repair; apoptosis; promotion; initiation;

D O I：

10.1134/S0006297908050076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Risk assessment in chemical carcinogenesis involves ratios of several factors. Individual responses of an organism to carcinogenic agents depend on polymorphism of enzymes responsible for metabolic activation/detoxification of carcinogens, DNA repair, and apoptosis, as well as promotion and progression in malignantly transformed cells. The effects of a particular polymorphic variant are manifested only in the case of its high penetrance. An integral effect is formed by the ratio of procarcinogenic and anticarcinogenic effects. The complexity of risk assessment depends on the gene polymorphism mosaic involved, directly or indirectly, in tumorigenesis and upstream/downstream interactions of gene products.

引用

页码：543 / 554

页数：12

共 55 条

[1]

ARCHAKOV A, 1989, FRONTIERS BIOTRANSFO, P151

[2] METABOLIC OXIDATION PHENOTYPES AS MARKERS FOR SUSCEPTIBILITY TO LUNG-CANCER [J].

AYESH, R ;

IDLE, JR ;

RITCHIE, JC ;

CROTHERS, MJ ;

HETZEL, MR .

NATURE, 1984, 312 (5990) :169-170

[3] THE PERSISTENCE OF LATENT TUMOUR CELLS INDUCED IN THE MOUSES SKIN BY A SINGLE APPLICATION OF 9-10-DIMETHYL-1-2-BENZANTHRACENE [J].

BERENBLUM, I ;

SHUBIK, P .

BRITISH JOURNAL OF CANCER, 1949, 3 (03) :384-386

[4] A single nucleotide polymorphism in the MDM2 gene:: From a molecular and cellular explanation to clinical effect [J].

Bond, GL ;

Hu, WW ;

Levine, A .

CANCER RESEARCH, 2005, 65 (13) :5481-5484

[5]

CAPORASO N, 1989, CANCER RES, V49, P3675

[6] Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer [J].

Chen, L ;

Elahi, A ;

Pow-Sang, J ;

Lazarus, P ;

Park, J .

JOURNAL OF UROLOGY, 2003, 170 (06) :2471-2474

[7] Modulation of liver X receptor signaling as novel therapy for prostate cancer [J].

Chuu, Chih-Pin ;

Kokontis, John M. ;

Hiipakka, Richard A. ;

Liao, Shutsung .

JOURNAL OF BIOMEDICAL SCIENCE, 2007, 14 (05) :543-553

[8] miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].

Cimmino, A ;

Calin, GA ;

Fabbri, M ;

Iorio, MV ;

Ferracin, M ;

Shimizu, M ;

Wojcik, SE ;

Aqeilan, RI ;

Zupo, S ;

Dono, M ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949

[9] STUDIES ON THE METABOLISM OF BENZO[A]PYRENE AND DOSE-DEPENDENT DIFFERENCES IN THE MUTAGENIC PROFILE OF ITS ULTIMATE CARCINOGENIC METABOLITE [J].

CONNEY, AH ;

CHANG, RL ;

JERINA, DM ;

WEI, SJC .

DRUG METABOLISM REVIEWS, 1994, 26 (1-2) :125-163

[10] DNA BINDING ACTIVITY FROM CULTURED HUMAN FIBROBLASTS THAT IS SPECIFIC FOR PARTIALLY DEPURINATED DNA AND THAT INSERTS PURINES INTO APURINIC SITES [J].

DEUTSCH, WA ;

LINN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) :141-144

← 1 2 3 4 5 6 →