Immunological aspects of microglia: relevance to Alzheimer's disease

被引：153

作者：

Benveniste, EN ^{[1
]}

Nguyen, VT ^{[1
]}

O'Keefe, GM ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2001年 / 39卷 / 5-6期

关键词：

microglia; Alzheimer's disease; immunology;

D O I：

10.1016/S0197-0186(01)00045-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a progressive dementing neurologic illness, and the most frequent cause of dementia in the elderly. Neuritic plaques are one of the main neuropathological findings in AD, and the major protein component is the beta -amyloid protein (A beta). Another striking feature of neuritic plaques is the presence of activated microglia, cytokines, and complement components, suggestive of "inflammatory foci" within AD brain. In this review, we will examine the mechanisms by which microglia become activated in AD, emphasizing the role in the A beta protein and proinflammatory cytokines. As well, pathways for suppression of microglial activation by immunosuppressive cytokines will be described. Inflammation mediated by activated microglia is an important component of AD pathophysiology. and strategies to control this response could provide new therapeutic approaches for the treatment of AD. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：381 / 391

页数：11

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