Cell culture-based models for intestinal permeability: a critique

被引:193
作者
Balimane, PV [1 ]
Chong, S [1 ]
机构
[1] Bristol Myers Squibb Co, Dept Metab & Pharmacokinet, Princeton, NJ 08543 USA
关键词
D O I
10.1016/S1359-6446(04)03354-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The model systems that are currently used to determine the intestinal permeability characteristics of discovery compounds often represent a combination of high throughput, but less predictive, in silico and in vitro models and low-throughput, but more predictive, in vivo models. Cell-based permeability models have been integrated into the discovery paradigm for some time and represent the 'method of choice' across the industry. Here, in addition to an objective analysis of the utility of cell culture models for permeability screening, anticipated future trends in the field of cell culture models are discussed.
引用
收藏
页码:335 / 343
页数:9
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