Structure of cytochrome c oxidase:: a comparison of the bacterial and mitochondrial enzymes

被引：47

作者：

Abramson, J

Svensson-Ek, M

Byrne, B

Iwata, S

机构：

[1] Univ Uppsala, Ctr Biomed, Dept Biochem, SE-75123 Uppsala, Sweden

[2] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AY, England

[3] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AY, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY | 2001年 / 1544卷 / 1-2期

关键词：

cytochrome c oxidase; X-ray crystallography; proton pump; membrane protein; proton pathway;

D O I：

10.1016/S0167-4838(00)00241-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been almost 5 years since the first structures of cytochrome c oxidase, from Paracoccus denitrificans and bovine heart mitochondria, were revealed. Since then many different proton pumping mechanisms have been proposed for the enzyme; however, no definitive conclusion has been achieved. In this article, we revisit the original structures of bacterial and mitochondrial oxidases and try to clarify similarities as well as differences between the two structures. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 9

页数：9

共 43 条

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