Triacylglycerol metabolism in adipose tissue

被引：140

作者：

Ahmadian, Mayam ^{[1
]}

Duncan, Robin E. ^{[1
]}

Jaworski, Kathy ^{[1
]}

Sarkadi-Nagy, Eszter ^{[1
]}

Sul, Hei Sook ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

FUTURE LIPIDOLOGY | 2007年 / 2卷 / 02期

关键词：

1-acylglycerol-3phosphate acyltransferase; desnutrin/adipose triglyceride lipase; diacylglycerol acyltransferase; glycerol-3phosphate acyltransferase; hormone-sensitive lipase; lipolysis; phosphatidic acid phosphatase; triacylglycerol;

D O I：

10.2217/17460875.2.2.229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.

引用

页码：229 / 237

页数：9

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