Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics

被引:205
作者
Pizzo, Paola
Pozzan, Tullio
机构
[1] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy
[2] Univ Padua, CNR, Inst Neurosci, I-35121 Padua, Italy
[3] Venetian Inst Mol Med, I-35129 Padua, Italy
关键词
D O I
10.1016/j.tcb.2007.07.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they interact both physically and functionally. A key aspect of the mitochondria-ER relationship is the modulation of Ca2+ signaling during cell activation, which thus affects a variety of physiological processes. We focus here on the molecular aspects that control the dynamics of the organelle-organelle interaction and their relationship with Ca2+ signals, also discussing the consequences that these phenomena have, not only for cell physiology but also in the control of cell death.
引用
收藏
页码:511 / 517
页数:7
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