Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication

Background: Little is known about the general population prevalence or severity of DSM-IV mental disorders. Objective: To estimate 12-month prevalence, severity, and comorbidity of DSM-IV anxiety, mood, impulse con trol, and substance disorders in the recently completed US National Comorbidity Survey Replication. Design and Setting: Nationally representative face-to-face household survey conducted between February 2001 and April 2003 using a fully structured diagnostic inter-view, the World Health Organization World Mental Health Survey Initiative version of the Composite International Diagnostic Interview. Participants: Nine thousand two hundred eighty-two English-speaking respondents 18 years and older. Main Outcome Measures: Twelve-month DSM-IV disorders. Results: Twelve-month prevalence estimates were anxiety, 18.1%; mood, 9.5%; impulse control, 8.9%; substance, 3.8%; and any disorder, 26.2%. Of 12-month cases, 22.3% were classified as serious; 37.3%, moderate; and 40.4%, mild. Fifty-five percent carried only a single diagnosis; 22%, 2 diagnoses; and 23%, 3 or more diagnoses. Latent class analysis detected 7 multivariate disorder classes, including 3 highly comorbid classes representing 7% of the population. Conclusion: Although mental disorders are widespread, serious cases are concentrated among a relatively small proportion of cases with high comorbidity.