New links to the pathogenesis of Crohn disease provided by genome-wide association scans

被引：160

作者：

Mathew, Christopher G. ^{[1
]}

机构：

[1] Guys Hosp, Univ London Kings Coll, London Sch Med, Div Genet & Mol Med, London SE1 9RT, England

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrg2203

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genome-wide association scans (GWAS) using large case-control samples and several hundred thousand genetic markers have uncovered at least ten new genomic regions associated with susceptibility to Crohn disease, a chronic inflammatory bowel disorder. The new loci include genes with diverse roles in the immune response and several gene deserts, which may contain regulatory sequences or encode novel functional transcripts. The results so far suggest that genome scans may re-define our ideas on the nature of causal variants in complex disease.

引用

页码：9 / 14

页数：6

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