Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses

被引：28

作者：

Saldana-Morales, Fatima B. ^{[1
,2
]}

Kim, Dasom V. ^{[2
,3
]}

Tsai, Ming-Ting ^{[1
,2
]}

Diehl, Gretchen E. ^{[2
,3
]}

机构：

[1] Baylor Coll Med, Grad Sch Biomed Sci, Houston, TX 77030 USA

[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Immunol Program, New York, NY 10021 USA

[3] Cornell Univ, Weill Cornell Med Coll, Immunol & Microbial Pathogenesis Program, New York, NY 10044 USA

来源：

GUT MICROBES | 2021年 / 13卷 / 01期

关键词：

Enteric nervous systems; mucosal immunity; intestinal epithelium; mucosal immune response; intestinal microbiota; PORE-FORMING TOXINS; GUT MICROBIOTA; BILE-ACIDS; MYCOBACTERIUM-TUBERCULOSIS; BACTERIAL FLAGELLIN; METABOLITE BUTYRATE; COMMENSAL BACTERIA; BARRIER FUNCTION; SENSORY NEURONS; PANETH CELLS;

D O I：

10.1080/19490976.2021.1916376

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

During both health and disease, a coordinated response between the epithelium, immune system, and enteric nervous system is required for proper intestinal function. While each system responds to a number of common stimuli, their coordinated responses support digestion as well as responses and recovery following injury or pathogenic infections. In this review, we discuss how individual responses to common signals work together to support these critical functions.

引用

收藏

页码：1 / 14

页数：14

相关论文

共 138 条

[1]

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease [J].

Abraham, Clara ;

Medzhitov, Ruslan .

GASTROENTEROLOGY, 2011, 140 (06) :1729-1737

[2]

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function [J].

Abreu, Maria T. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (02) :131-143

[3]

Local immune response to food antigens drives meal-induced abdominal pain [J].

Aguilera-Lizarraga, Javier ;

Florens, Morgane, V ;

Viola, Maria Francesca ;

Jain, Piyush ;

Decraecker, Lisse ;

Appeltans, Iris ;

Cuende-Estevez, Maria ;

Fabre, Naomi ;

Van Beek, Kim ;

Perna, Eluisa ;

Balemans, Dafne ;

Stakenborg, Nathalie ;

Theofanous, Stavroula ;

Bosmans, Goele ;

Mondelaers, Stephanie U. ;

Matteoli, Gianluca ;

Martinez, Sales Ibiza ;

Lopez-Lopez, Cintya ;

Jaramillo-Polanco, Josue ;

Talavera, Karel ;

Alpizar, Yeranddy A. ;

Feyerabend, Thorsten B. ;

Rodewald, Hans-Reimer ;

Farre, Ricard ;

Redegeld, Frank A. ;

Si, Jiyeon ;

Raes, Jeroen ;

Breynaert, Christine ;

Schrijvers, Rik ;

Bosteels, Cedric ;

Lambrecht, Bart N. ;

Boyd, Scott D. ;

Hoh, Ramona A. ;

Cabooter, Deirdre ;

Nelis, Maxim ;

Augustijns, Patrick ;

Hendrix, Sven ;

Strid, Jessica ;

Bisschops, Raf ;

Reed, David E. ;

Vanner, Stephen J. ;

Denadai-Souza, Alexandre ;

Wouters, Mira M. ;

Boeckxstaens, Guy E. .

NATURE, 2021, 590 (7844) :151-+

[4]

Clostridium difficile Toxin Biology [J].

Aktories, Klaus ;

Schwan, Carsten ;

Jank, Thomas .

ANNUAL REVIEW OF MICROBIOLOGY, VOL 71, 2017, 71 :281-307

[5]

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release [J].

Alcaino, Constanza ;

Knutson, Kaitlyn R. ;

Treichel, Anthony J. ;

Yildiz, Gulcan ;

Strege, Peter R. ;

Linden, David R. ;

Li, Joyce H. ;

Leiter, Andrew B. ;

Szurszewski, Joseph H. ;

Farrugia, Gianrico ;

Beyder, Arthur .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (32) :E7632-E7641

[6]

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice [J].

Alemi, Farzad ;

Poole, Daniel P. ;

Chiu, Jonathan ;

Schoonjans, Kristina ;

Cattaruzza, Fiore ;

Grider, John R. ;

Bunnett, Nigel W. ;

Corvera, Carlos U. .

GASTROENTEROLOGY, 2013, 144 (01) :145-154

[7]

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity [J].

Allaire, Joannie M. ;

Crowley, Shauna M. ;

Law, Hong T. ;

Chang, Sun-Young ;

Ko, Hyun-Jeong ;

Vallance, Bruce A. .

TRENDS IN IMMUNOLOGY, 2018, 39 (09) :677-696

[8]

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling [J].

Anitha, Mallappa ;

Vijay-Kumar, Matam ;

Sitaraman, Shanthi V. ;

Gewirtz, Andrew T. ;

Srinivasan, Shanthi .

GASTROENTEROLOGY, 2012, 143 (04) :1006-+

[9]

BILE-SALT INHIBITION OF MOTILITY IN THE ISOLATED PERFUSED RABBIT TERMINAL ILEUM [J].

ARMSTRONG, DN ;

KRENZ, HK ;

MODLIN, IM ;

BALLANTYNE, GH .

GUT, 1993, 34 (04) :483-488

[10]

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

← 1 2 3 4 5 6 7 8 9 10 →