Utah family-based analysis: Past, present and future

被引：60

作者：

Albright, Lisa A. Cannon ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biomed Informat, Div Genet Epidemiol, Salt Lake City, UT 84108 USA

来源：

HUMAN HEREDITY | 2008年 / 65卷 / 04期

关键词：

family-based analysis; UPDB; high-risk pedigrees;

D O I：

10.1159/000112368

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A unique genealogical resource linked to phenotype data was created in Utah over 30 years ago. Here we review the history and content of this resource. In addition, we review three current methodologies used in conjunction with this resource to define the heritable contribution to phenotypes and to identify predisposition genes responsible for these phenotypes. Example analyses and high-risk pedigrees are presented. Finally we briefly review ways this resource, or others like it, may expand in future.

引用

页码：209 / 220

页数：12

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