Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei

被引：20

作者：

Kanfer, JN ^{[1
]}

McCartney, DG ^{[1
]}

Singh, IN ^{[1
]}

Freysz, L ^{[1
]}

机构：

[1] CTR NEUROCHIM,F-67084 STRASBOURG,FRANCE

来源：

FEBS LETTERS | 1996年 / 383卷 / 1-2期

关键词：

phospholipase D; neuronal nuclei; phosphatidic acid; phosphatidylinositol-4,5-diphosphate; acidic phospholipids;

D O I：

10.1016/0014-5793(96)00205-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An oleate dependent form of phospholipase D is present in rat brain neuronal nuclei and both the hydrolytic and transphosphatidylation activities measured. Several acidic phospholipids were found to inhibit this activity in a dose dependent manner. The IC50 values varied from 3.5 mu M for PIP2 to 200 mu M for phosphatidic acid. The hydrolysis of PIP2 by phospholipase C would be expected to result in the disinhibition of the oleate dependent phospholipase D activity.

引用

页码：6 / 8

页数：3

共 28 条

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