Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed

被引：53

作者：

Bujnicki, JM

Radlinska, M

Rychlewski, L

机构：

[1] Int Inst Mol & Cell Biol, Bioinformat Lab, PL-02109 Warsaw, Poland

[2] Warsaw Univ, Inst Microbiol, PL-02093 Warsaw, Poland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(00)01690-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture a nd fold from the "typical" PD-(D/E)xK superfamily, These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.

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页码：9 / 11

页数：3

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