Causation of chronic lymphocytic leukemia - insights from familial disease

被引：36

作者：

Houlston, RS ^{[1
]}

Sellick, G

Yuille, M

Matutes, E

Catovsky, D

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Acad Dept Haematol & Cytogenet, Sutton SM2 5NG, Surrey, England

来源：

LEUKEMIA RESEARCH | 2003年 / 27卷 / 10期

关键词：

inherited susceptibility; chronic lymphocytic leukemia;

D O I：

10.1016/S0145-2126(03)00023-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In Western countries B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia. Evidence from epidemiological studies and family studies strongly supports the notion that a subset of CLL involves inherited susceptibility. Identification of genes predisposing to CLL should be useful for diagnosis and treatment, as well as serving as a model for B-cell tumorigenesis in general. Here, we review the current status of knowledge about inherited susceptibility to CLL. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：871 / 876

页数：6

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