Biological and clinical role of p73 in neuroblastoma

被引：16

作者：

Romani, A

Tonini, GP

Banelli, B

Allemanni, G

Mazzocco, K

Scaruffi, P

Boni, L

Ponzoni, M

Pagnan, G

Raffaghello, L

Ferrini, S

Croce, M

Casciano, I

机构：

[1] Ist Nazl Ric Canc, IST, Lab Tumor Genet, I-16132 Genoa, Italy

[2] CBA, Neuroblastoma Res Lab, I-16132 Genoa, Italy

[3] CBA, Biomed Technol Assessment, I-16132 Genoa, Italy

[4] Ist Giannina Gaslini, Differentiat Therapy Unit, I-16147 Genoa, Italy

[5] Ist Nazl Ric Canc, IST, Lab Immunopharmacol, I-16132 Genoa, Italy

来源：

CANCER LETTERS | 2003年 / 197卷 / 1-2期

关键词：

neuroblastoma; p73; apoptosis; tumor suppressor gene; methylation;

D O I：

10.1016/S0304-3835(03)00092-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was originally considered an oncosuppressor gene. However, it was soon realized that its mode of action did not resemble that of a classic anti-oncogene. The recent discovery of N-terminal truncated isoforms, with oncogenic properties, showed that p73 has a 'two in one' structure. Indeed, the full-length variants are strong inducers of apoptosis while the truncated isoforms inhibit the pro-apoptotic activity of p53 and of the full-length p73. This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：111 / 117

页数：7

相关论文

共 19 条

[1] Methylation-independent silencing of the p73 gene in neuroblastoma [J].

Banelli, B ;

Casciano, I ;

Romani, M .

ONCOGENE, 2000, 19 (39) :4553-4556

[2] Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients [J].

Casciano, I ;

Mazzocco, K ;

Boni, L ;

Pagnan, G ;

Banelli, B ;

Allemanni, G ;

Ponzoni, M ;

Tonini, GP ;

Romani, M .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (03) :246-251

[3] Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma [J].

Casciano, I ;

Ponzoni, M ;

Lo Cunsolo, C ;

Tonini, GP ;

Romani, M .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (05) :391-393

[4] Role of methylation in the control of ΔNp73 expression in neuroblastoma [J].

Casciano, I ;

Banelli, B ;

Croce, M ;

Allemanni, G ;

Ferrini, S ;

Tonini, GP ;

Ponzoni, M ;

Romani, M .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (03) :343-345

[5] Additional complexity in p73:: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ [J].

De Laurenzi, V ;

Catani, MV ;

Terrinoni, A ;

Corazzari, M ;

Melino, G ;

Costanzo, A ;

Levrero, M ;

Knight, RA .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (05) :389-390

[6] p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent [J].

Ichimiya, S ;

Nimura, Y ;

Kageyama, H ;

Takada, N ;

Sunahara, M ;

Shishikura, T ;

Nakamura, Y ;

Sakiyama, S ;

Seki, N ;

Ohira, M ;

Kaneko, Y ;

McKeon, F ;

Caput, D ;

Nakagawara, A .

ONCOGENE, 1999, 18 (04) :1061-1066

[7] Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers [J].

Kaghad, M ;

Bonnet, H ;

Yang, A ;

Creancier, L ;

Biscan, JC ;

Valent, A ;

Minty, A ;

Chalon, P ;

Lelias, JM ;

Dumont, X ;

Ferrara, P ;

McKeon, F ;

Caput, D .

CELL, 1997, 90 (04) :809-819

[8]

Kovalev S, 1998, CELL GROWTH DIFFER, V9, P897

[9] Refined chromosomal localization of the putative tumor suppressor gene TP73 [J].

Lo Cunsolo, C ;

Casciano, I ;

Banelli, B ;

Tonini, GP ;

Romani, M .

CYTOGENETICS AND CELL GENETICS, 1998, 82 (3-4) :199-201

[10] p73: Friend or foe in tumorigenesis [J].

Melino, G ;

De Laurenzi, V ;

Vousden, KH .

NATURE REVIEWS CANCER, 2002, 2 (08) :605-615