Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation

被引：50

作者：

Miller, VT ^{[1
]}

Pearce, LA ^{[1
]}

Feinberg, WM ^{[1
]}

Rothrock, JF ^{[1
]}

Anderson, DC ^{[1
]}

Hart, RG ^{[1
]}

机构：

[1] STAT & EPIDEMIOL RES CORP, SEATTLE, WA 98195 USA

来源：

NEUROLOGY | 1996年 / 46卷 / 01期

关键词：

D O I：

10.1212/WNL.46.1.238

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated with these two drugs, warfarin proved significantly more effective than aspirin in preventing cardioembolic strokes (p = 0.005) and strokes of uncertain pathophysiology (p = 0.01). There was no significant difference in the efficacy for prevention of noncardioembolic strokes.

引用

页码：238 / 240

页数：3

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