Controlling skin morphogenesis: hope and despair

被引：40

作者：

Brouard, M

Barrandon, Y ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Sch Life Sci, Lab Stem Cell Dynam, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne Hosp, Dept Expt Surg, CH-1015 Lausanne, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.copbio.2003.09.005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To master tissue and organ morphogenesis necessitates a thorough understanding of the cellular and molecular events involved in development, renewal, repair and regeneration. Skin reconstruction is the paradigm of tissue engineering. The transplantation of autologous adult epidermal stem cells is a life-saving procedure as it regenerates the indispensable barrier function of the skin, but the reconstruction of fully functional skin has been hampered by the complexity of the process. The recent identification of multipotent epithelial stem cells in adult hair follicles and of multipotent stem cells in dermis raises new hopes.

引用

页码：520 / 525

页数：6

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