Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

被引：61

作者：

Cutlip, DE

Ricciardi, MJ

Ling, FS

Carrozza, JP

Dua, V

Garringer, J

Giri, S

Caputo, RP

机构：

[1] Beth Israel Deaconess Med Ctr, Intervent Cardiol Sect, Boston, MA 02215 USA

[2] Northwestern Univ, Med Ctr, Div Cardiol, Chicago, IL 60611 USA

[3] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

[4] Brigham & Womens Hosp, Angiograph Core Lab, Boston, MA 02115 USA

[5] St Josephs Hosp, Cardiol Unit, Dept Med, Cardiac Catheterizat Associates, Syracuse, NY USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(03)00983-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07). (C) 2003 by Excerpta Medica, Inc.

引用

页码：977 / 980

页数：4

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