Voriconazole-induced QT interval prolongation and ventricular tachycardia: A non-concentration-dependent adverse effect

被引：50

作者：

Alkan, Y

Haefeli, WE

Burhenne, J

Stein, J

Yaniv, I

Shalit, I

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Dept Pediat Hematol Oncol, IL-69978 Tel Aviv, Israel

[3] Univ Heidelberg, Dept Internal Med 6, Heidelberg, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 06期

关键词：

D O I：

10.1086/423275

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.

引用

页码：E49 / E52

页数：4

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