Palladium-catalyzed aminocarbonylation of aryl chlorides at atmospheric pressure: The dual role of sodium phenoxide

被引：289

作者：

Martinelli, Joseph R. ^{[1
]}

Clark, Thomas P. ^{[1
]}

Watson, Donald A. ^{[1
]}

Munday, Rachel H. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 44期

关键词：

amides; aryl chlorides; carbonylation; palladium; phosphines; CARBON-MONOXIDE; CARBONYLATION; ALKOXYCARBONYLATION; CONVENIENT; BROMIDES;

D O I：

10.1002/anie.200702943

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) No pressure, no worries: A general, functional-group-tolerant, mild system for the Pd-catalyzed carbonylation of aryl chlorides to the corresponding amides has been developed. The catalyst operates at 1 atm CO using an inexpensive, air-stable, and commercially available ligand (see scheme, Cy = cyclohexyl). Sodium phenoxide is a critical additive in this transformation; its role has been studied using in situ IR spectroscopy. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8460 / 8463

页数：4

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