共 62 条
Multiple functions of type 10 17β-hydroxysteroid dehydrogenase
被引:106
作者:

Yang, SY
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机构: New York State Inst Basic Res Dev Disabil, Dept Pharmacol, Staten Isl, NY 10314 USA

He, XY
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机构: New York State Inst Basic Res Dev Disabil, Dept Pharmacol, Staten Isl, NY 10314 USA

Schulz, H
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机构: New York State Inst Basic Res Dev Disabil, Dept Pharmacol, Staten Isl, NY 10314 USA
机构:
[1] New York State Inst Basic Res Dev Disabil, Dept Pharmacol, Staten Isl, NY 10314 USA
[2] CUNY City Coll, Dept Chem & Biochem, New York, NY 10031 USA
关键词:
D O I:
10.1016/j.tem.2005.03.006
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Human 17 beta-hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which escapes chromosome X inactivation. 17 beta-HSD10/SCHAD mutations cause a spectrum of clinical conditions, from mild mental retardation to progressive infantile neurodegeneration. 17 beta-HSD10/SCHAD is essential for the metabolism of isoleucine and branched-chain fatty acids. It can inactivate 17 beta-estradiol and steroid modulators of GABA(A) receptors, and convert 5 alpha-androstanediol into 5 alpha-dihydrotestosterone (DHT). Certain malignant prostatic epithelial cells contain high levels of 17 beta-HSD10, generating 5 alpha-DHT in the absence of testosterone. 17 beta-HSD10 has an affinity for amyloid-beta peptide, and might be linked to the mitochondrial dysfunction seen in Alzheimer's disease. This versatile enzyme might provide a new drug target for neuronal excitability control and for intervention in Alzheimer's disease and certain cancers.
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页码:167 / 175
页数:9
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