Porous Scaffolds Based on Cross-Linking of Poly(L-glutamic acid)

被引：41

作者：

Cao, Bin ^{[1
]}

Yin, Jingbo ^{[1
]}

Yan, Shifeng ^{[1
]}

Cui, Lei ^{[2
]}

Chen, Xuesi ^{[3
]}

Xie, Yongtao ^{[1
]}

机构：

[1] Shanghai Univ, Dept Polymer Mat, Shanghai, Peoples R China

[2] Natl Tissue Engn Ctr China, Shanghai, Peoples R China

[3] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biological application of polymers; biomimetic; chitosan; crosslinking; mechanical; HIGH-MOLECULAR-WEIGHT; L-GLUTAMIC ACID; BIOMIMETIC MATERIALS; MEMBRANE; DELIVERY; CHITOSAN; POLYPEPTIDES;

D O I：

10.1002/mabi.201000389

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Porous scaffolds based on water-soluble PLGA and CS were prepared. The pores were verified to be alveolate, uniformand continuous. The effects of freezing temperature, freeze-drying time, solid content and molecular weight of reactants on the pore structure of the scaffolds were studied. The scaffold morphology could be adjusted by changing the freezing temperature and solid content of reacting polymer. Their degradation rate can be adjusted by changing the proportion of PLGA and CS. The porosity of scaffolds was higher than 90% and the high swelling ratio showed that these scaffolds had excellent hydrophilic performance. The in vitro culture of chondrocytes indicates that the obtained PLGA/CS porous scaffolds are very promising biomaterials for tissue engineering applications.

引用

页码：427 / 434

页数：8

共 23 条

[1]

The basement membrane component of biologic scaffolds derived from extracellular matrix [J].