Contrasting models of promiscuous gene expression by thymic epithelium

被引：53

作者：

Gillard, GO

Farr, AG ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biostruct, Sch Med, Seattle, WA 98195 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 01期

关键词：

D O I：

10.1084/jem.20050976

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue-restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model - whereby TRA expression is regulated by conserved developmental programs active in developing mTECs - may be equally plausible.

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页码：15 / 19

页数：5

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