Pharmacotherapy for intestinal motor and sensory disorders

被引：25

作者：

Hasler, WL ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2003年 / 32卷 / 02期

关键词：

D O I：

10.1016/S0889-8553(03)00027-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Motor disorders of the gastrointestinal tract are characterized by definable impairments of gut contractile function. Other conditions exhibit specific disturbances of visceral afferent and efferent activity, which may underlie selected symptom complexes. Medications in several classes have been developed to treat these disorders of gastrointestinal function. Prokinetic agents are effective therapies for ailments with reduced motor function, whereas antispasmodic drugs reduce symptoms in conditions with exaggerated pressure wave activity. Recently, medications designed to blunt transmission in visceral sensory pathways have been proposed for use in the functional bowel disorders. Finally, some patients may benefit from initiation of nonspecific therapies, which have no appreciable effect on gut motor or sensory function.

引用

页码：707 / +

页数：28

共 124 条

[1]

Abitbol JL, 1996, GASTROENTEROLOGY, V110, pA622

[2]

ANDREWS PLR, 1991, IRRITABLE BOWEL SYND, P91

[3]

Bardhan KD, 2000, ALIMENT PHARM THERAP, V14, P23

[4] Dose-related stimulatory effect of clarithromycin on interdigestive gastroduodenal motility [J].

Bortolotti, M ;

Annese, V ;

Mari, C ;

Lopilato, C ;

Porrazzo, G ;

Miglioli, M .

DIGESTION, 2000, 62 (01) :31-37

[5] Effects of sildenafil on esophageal motility of normal subjects [J].

Bortolotti, M ;

Mari, C ;

Giovannini, M ;

Pinna, S ;

Miglioli, M .

DIGESTIVE DISEASES AND SCIENCES, 2001, 46 (11) :2301-2306

[6] A double-blind randomised placebo-controled crossover trial of citalopram, a selective 5-hydroxytryptamine reuptake inhibitor, in irritable bowel syndrome. [J].

Broekaert, D ;

Vos, R ;

Gevers, AM ;

Janssens, J ;

Vandenberghe, J ;

Fischler, B ;

Tack, J .

GASTROENTEROLOGY, 2001, 120 (05) :A641-A641

[7] DOMPERIDONE - A REVIEW OF ITS PHARMACOLOGICAL ACTIVITY, PHARMACOKINETICS AND THERAPEUTIC EFFICACY IN THE SYMPTOMATIC TREATMENT OF CHRONIC DYSPEPSIA AND AS AN ANTIEMETIC [J].

BROGDEN, RN ;

CARMINE, AA ;

HEEL, RC ;

SPEIGHT, TM ;

AVERY, GS .

DRUGS, 1982, 24 (05) :360-400

[8]

Camilleri M, 2002, GASTROENTEROLOGY, V122, pA59

[9]

Camilleri M, 1999, ALIMENT PHARM THERAP, V13, P1149

[10] Review article: tegaserod [J].

Camilleri, M .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (03) :277-289

← 1 2 3 4 5 6 7 8 9 10 →