The habenula is crucial for experience-dependent modification of fear responses in zebrafish

被引：285

作者：

Agetsuma, Masakazu

Aizawa, Hidenori

Aoki, Tazu

Nakayama, Ryoko ^{[1
]}

Takahoko, Mikako ^{[1
]}

Goto, Midori

Sassa, Takayuki

Amo, Ryunosuke ^{[2
]}

Shiraki, Toshiyuki ^{[1
]}

Kawakami, Koichi ^{[3
,4
]}

Hosoya, Toshihiko

Higashijima, Shin-ichi ^{[5
]}

Okamoto, Hitoshi ^{[6
]}

机构：

[1] RIKEN Brain Sci Inst, Res Resource Ctr, Wako, Saitama, Japan

[2] Waseda Univ, Grad Sch Adv Sci & Engn, Dept Life Sci & Med Biosci, Shinjuku Ku, Tokyo, Japan

[3] Natl Inst Genet, Div Mol & Dev Biol, Shizuoka, Japan

[4] Grad Univ Adv Studies, Dept Genet, Shizuoka, Japan

[5] Natl Inst Physiol Sci, Okazaki Inst Integrat Biosci, Natl Inst Nat Sci, Aichi, Japan

[6] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Chiyoda Ku, Tokyo, Japan

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

NUCLEUS; CONNECTIONS; EXPRESSION;

D O I：

10.1038/nn.2654

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.

引用

页码：1354 / 1356

页数：3

共 15 条

[1] Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus [J].