Lack of bioeffects of ultrasound energy after intravenous administration of FS069 (Optison) in the anesthetized rabbit

被引：20

作者：

Killam, AL

Greener, Y

McFerran, BA

Maniquis, J

Bloom, A

Widder, KJ

Dittrich, HC

机构：

[1] Mol Biosyst Inc, San Diego, CA 92121 USA

[2] Univ Calif San Diego, Med Ctr, San Diego, CA 92121 USA

来源：

JOURNAL OF ULTRASOUND IN MEDICINE | 1998年 / 17卷 / 06期

关键词：

D O I：

10.7863/jum.1998.17.6.349

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The current study was designed to provide a sensitive in vivo model to maximize the potential bioeffects (measured by hemolysis) of B-mode ultrasound energy in combination with FS069 (Optison). B-mode ultrasound energy was delivered to anesthetized male New Zealand white rabbits with a phased array 5 MHz transducer on a Hewlett-Packard Sonos 1500 ultrasonograph, with transmit level set to maximum (40 dB, approx 135 W/cm(2)). FS069 (Optison), latex particles in human albumin, or human albumin alone (vehicle) was infused via an ear vein at 0.6 mL/kg. No statistically significant changes were noted in serum free hemoglobin or lactate dehydrogenase either over time or between groups.

引用

页码：349 / 356

页数：8

共 26 条

[1] EFFECT OF A STABILIZED MICROBUBBLE ECHO CONTRAST AGENT ON HEMOLYSIS OF HUMAN ERYTHROCYTES EXPOSED TO HIGH-INTENSITY PULSED ULTRASOUND [J].

BRAYMAN, AA ;

AZADNIV, M ;

MAKIN, IRS ;

MILLER, MW ;

CARSTENSEN, EL ;

CHILD, SZ ;

RAEMAN, CH ;

MELTZER, RS ;

EVERBACH, EC .

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 1995, 12 (01) :13-21

[2]

BROWN JM, 1995, RADIOLOGY, V197, P286

[3]

CAMARANO GP, 1994, CIRCULATION, V90, P68

[4]

COHEN Y, 1968, NT J APPL RAD ISOT, V19, P703

[5]

Dittrich H C, 1995, J Am Soc Echocardiogr, V8, P465, DOI 10.1016/S0894-7317(05)80333-5

[6]

EASTON TW, 1956, AM J ANAT, V90, P1

[7]

FORSBERG F, 1995, RADIOLOGY, V197, P403

[8]

FORSBERG F, 1995, J ULTRASOUND MED S3, V14, pS67

[9] Direct evidence of cavitation in vivo from diagnostic ultrasound [J].

Holland, CK ;

Deng, CX ;

Apfel, RE ;

Alderman, JL ;

Fernandez, LA ;

Taylor, KJW .

ULTRASOUND IN MEDICINE AND BIOLOGY, 1996, 22 (07) :917-925

[10] MEMBRANE VERSUS BUBBLE OXYGENATOR IN HYPERTHERMIC REGIONAL PERFUSION - A PROSPECTIVE RANDOMIZED CLINICAL-STUDY [J].

HUBER, R ;

MENNICKE, C ;

HEITMANN, KU ;

HELLING, HJ ;

HUBER, PM .

EUROPEAN SURGICAL RESEARCH, 1994, 26 (04) :210-220

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