A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure

被引：40

作者：

Papageorgiou, C

Borer, X

机构：

[1] Sandoz Pharma Ltd., Preclinical Research

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/0960-894X(96)00003-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 1,3,4-trisubstituted-1,4-benzodiazepin-2-one 2 is a non-peptide mimic of somatostatin 1. It displaces the radioligand [I-125-Tyr(3)]-octreotide with an IC50 Of 7 mu M.

引用

页码：267 / 272

页数：6

共 23 条

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