Assessing the human immune system through blood transcriptomics

被引：179

作者：

Chaussabel, Damien ^{[1
]}

Pascual, Virginia

Banchereau, Jacques

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

来源：

BMC BIOLOGY | 2010年 / 8卷

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION PROFILES; JUVENILE IDIOPATHIC ARTHRITIS; LIVER-TRANSPLANT RECIPIENTS; MULTIPLE-SCLEROSIS PATIENTS; RENAL-ALLOGRAFT REJECTION; INTERFERON-BETA THERAPY; CIRCULATING TUMOR-CELLS; YELLOW-FEVER VACCINE; FALSE DISCOVERY RATE; PERIPHERAL-BLOOD;

D O I：

10.1186/1741-7007-8-84

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed.

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页数：14

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