Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population

被引：25

作者：

Matsushita, Tomonaga ^{[1
,2
]}

Umeno, Junji ^{[1
,2
]}

Hirakawa, Yoichiro ^{[3
]}

Yonemoto, Koji ^{[3
]}

Ashikawa, Kyota ^{[1
]}

Amitani, Hanae ^{[1
]}

Ninomiya, Toshiharu ^{[3
]}

Hata, Jun ^{[3
]}

Doi, Yasufumi ^{[3
]}

Kitazono, Takanari ^{[2
]}

Iida, Mitsuo ^{[2
]}

Nakamura, Yusuke ^{[4
]}

Kiyohara, Yutaka ^{[3
]}

Kubo, Michiaki ^{[1
,2
,3
]}

机构：

[1] RIKEN, Lab Genotyping Dev, Ctr Genom Med, Yokohama Inst, Kanagawa 2300045, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Clin Studies, Fukuoka 812, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka 812, Japan

[4] Univ Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2010年 / 55卷 / 07期

关键词：

atherothrombotic stroke; replication study; SNP;

D O I：

10.1038/jhg.2010.45

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case-control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs on the subtypes of ischemic stroke. Association analysis was carried out using logistic regression model after adjustment of age, sex and cardiovascular risk factors. Rs12425791 was significantly associated with atherothrombotic stroke (P=0.0084, odds ratio (OR)=1.15). When we analyzed effects of rs12425791 on ischemic stroke subtypes, rs12425791 was significantly associated with both small-artery occlusion (P=0.015, OR=1.15) and large-artery atherosclerosis (P=0.024, OR=1.19). Rs11833579 showed no association with atherothrombotic stroke or its subtypes in our population. Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population. Journal of Human Genetics (2010) 55, 473-476; doi:10.1038/jhg.2010.45; published online 7 May 2010

引用

页码：473 / 476

页数：4

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