Three-dimensional intricacies in protein-DNA recognition and transcriptional control

被引：6

作者：

Harrison, Stephen C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 12期

关键词：

D O I：

10.1038/nsmb1207-1118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factors 'recognize' relatively short DNA consensus sequences; their full specificity must depend on a broader set of protein-protein and protein-DNA interactions. Joshi et al. show that, in addition to forming base pair - specific hydrogen bonds in the DNA major groove, certain Hox proteins detect DNA shape in the minor groove.

引用

页码：1118 / 1119

页数：2

共 10 条

[1] RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE-434 - A VIEW AT HIGH-RESOLUTION [J].

AGGARWAL, AK ;

RODGERS, DW ;

DROTTAR, M ;

PTASHNE, M ;

HARRISON, SC .

SCIENCE, 1988, 242 (4880) :899-907

[2] HOMEODOMAIN-DNA RECOGNITION [J].

GEHRING, WJ ;

QIAN, YQ ;

BILLETER, M ;

FURUKUBOTOKUNAGA, K ;

SCHIER, AF ;

RESENDEZPEREZ, D ;

AFFOLTER, M ;

OTTING, G ;

WUTHRICH, K .

CELL, 1994, 78 (02) :211-223

[3] Functional specificity of a Hox protein mediated by the recognition of minor groove structure [J].

Joshi, Rohit ;

Passner, Jonathan M. ;

Rohs, Remo ;

Jain, Rinku ;

Sosinsky, Alona ;

Crickmore, Michael A. ;

Jacob, Vinitha ;

Aggarwal, Aneel K. ;

Honig, Barry ;

Mann, Richard S. .

CELL, 2007, 131 (03) :530-543

[4] CRYSTAL-STRUCTURE OF AN ENGRAILED HOMEODOMAIN-DNA COMPLEX AT 2.8-A RESOLUTION - A FRAMEWORK FOR UNDERSTANDING HOMEODOMAIN-DNA INTERACTIONS [J].

KISSINGER, CR ;

LIU, BS ;

MARTINBLANCO, E ;

KORNBERG, TB ;

PABO, CO .

CELL, 1990, 63 (03) :579-590

[5] CRYSTAL-STRUCTURE OF THE MATA1/MAT-ALPHA-2 HOMEODOMAIN HETERODIMER BOUND TO DNA [J].

LI, T ;

STARK, MR ;

JOHNSON, AD ;

WOLBERGER, C .

SCIENCE, 1995, 270 (5234) :262-269

[6] An atomic model of the interferon-β enhanceosome [J].

Panne, Daniel ;

Maniatis, Tom ;

Harrison, Stephen C. .

CELL, 2007, 129 (06) :1111-1123

[7] Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex [J].

Passner, JM ;

Ryoo, HD ;

Shen, LY ;

Mann, RS ;

Aggarwal, AK .

NATURE, 1999, 397 (6721) :714-719

[8] Modulating Hox gene functions during animal body patterning [J].

Pearson, JC ;

Lemons, D ;

McGinnis, W .

NATURE REVIEWS GENETICS, 2005, 6 (12) :893-904

[9] Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation [J].

Piper, DE ;

Batchelor, AH ;

Chang, CP ;

Cleary, ML ;

Wolberger, C .

CELL, 1999, 96 (04) :587-597

[10] THE STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN DETERMINED BY NMR-SPECTROSCOPY IN SOLUTION - COMPARISON WITH PROKARYOTIC REPRESSORS [J].

QIAN, YQ ;

BILLETER, M ;

OTTING, G ;

MULLER, M ;

GEHRING, WJ ;

WUTHRICH, K .

CELL, 1989, 59 (03) :573-580

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