Cytochrome P4501A1 polymorphisms in the Amerindian and mestizo populations of Mexico

被引:11
作者
Fragoso, JM
Juárez-Cedillo, T
Hernández-Pacheco, G
Ramírez, E
Zuñiga, J
Izaguirre, R
de la Peña, A
Granados, J
Vargas-Alarón, G
机构
[1] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Mexico City 14080, DF, Mexico
[2] Inst Nacl Cardiol Ignacio Chavez, Dept Hematol, Mexico City 14080, DF, Mexico
[3] Inst Nacl Enfermedades Resp, Infect Dis Unit, Mol Biol & Immunogenet Lab, Mexico City, DF, Mexico
[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico
关键词
Amerindians; cytochrome P450; genotype; Mexican populations; polymerase chain reaction; polymorphism; susceptibility;
D O I
10.1002/cbf.1174
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Mexican Mestizos, 52 Teenek and 54 Mayos). Comparison among Mexican populations showed increased frequency of the *Ile allele (A on position 4889) in Mexican Mestizos when compared to Amerindians (p < 0.05). The analysis of position 6235 showed increased frequencies of *m2 (C in this position) allele in Teenek when compared to Mestizos and Mayos (p < 0.05) and of *m2/*m2 genotype when compared to Mestizos (p < 0.05). Amerindian populations (from Mexico and South America) presented the lowest frequencies of *Ile (position 4889) and *m1 (position 6235) alleles, however these frequencies vary according to the ethnic group studied. Mexican Amerindian groups together with other South Amerindian populations showed the highest frequencies for *Val at position 4889 and the *m2 allele at position 6235. The present study corroborates the high frequencies of *Val and *m2 alleles in the Amerindian populations and detects some differences between Mexican populations that correlate with linguistic differences. Our data could be helpful in understanding the distribution of these polymorphisms and in clarifying their roles as genetic and evolution markers in Amerindian populations. Copyright (c) 2004 John Wiley & Sons, Ltd.
引用
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页码:189 / 193
页数:5
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