Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

被引：237

作者：

Haveri, Anu ^{[1
]}

Smura, Teemu ^{[2
]}

Kuivanen, Suvi ^{[2
]}

Osterlund, Pamela ^{[1
]}

Hepojoki, Jussi ^{[2
,3
]}

Ikonen, Niina ^{[1
]}

Pitkapaasi, Marjaana ^{[1
]}

Blomqvist, Soile ^{[1
]}

Ronkko, Esa ^{[1
]}

Kantele, Anu ^{[4
,5
]}

Strandin, Tomas ^{[2
]}

Kallio-Kokko, Hannimari ^{[5
,6
]}

Mannonen, Laura ^{[5
,6
]}

Lappalainen, Maija ^{[5
,6
]}

Broas, Markku ^{[7
]}

Jiang, Miao ^{[1
,8
]}

Siira, Lotta ^{[1
]}

Salminen, Mika ^{[1
]}

Puumalainen, Taneli ^{[1
]}

Sane, Jussi ^{[1
]}

Melin, Merit ^{[1
]}

Vapalahti, Olli ^{[2
,5
,6
]}

Savolainen-Kopra, Carita ^{[1
]}

机构：

[1] Finnish Inst Hlth & Welf THL, Dept Hlth Secur, Helsinki, Finland

[2] Univ Helsinki, Dept Virol, Med, Helsinki, Finland

[3] Univ ZUrich, Vetsuisse Fac, Inst Vet Pathol, Zurich, Switzerland

[4] Helsinki Univ Hosp HUSLAB, Inflammat Ctr, Infect Dis, Helsinki, Finland

[5] Univ Helsinki, Helsinki, Finland

[6] Helsinki Univ Hosp HUSLAB, Dept Virol & Immunol, Helsinki, Finland

[7] Lapland Cent Hosp, Infect Hosp Hyg Unit, Rovaniemi, Finland

[8] Univ Helsinki, Fac Biol & Environm Sci, Helsinki, Finland

来源：

EUROSURVEILLANCE | 2020年 / 25卷 / 11期

关键词：

ACUTE RESPIRATORY SYNDROME; SYNDROME-ASSOCIATED CORONAVIRUS; SARS; 229E;

D O I：

10.2807/1560-7917.ES.2020.25.11.2000266

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

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页码：16 / 21

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