Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient

被引：62

作者：

Cubero, Maria ^{[1
,2
,3
]}

Esteban, Juan Ignacio ^{[1
,2
,3
]}

Otero, Teresa ^{[1
]}

Sauleda, Silvia ^{[3
,4
]}

Bes, Marta ^{[3
,4
]}

Esteban, Rafael ^{[1
,2
,3
]}

Guardia, Jaurne ^{[1
,2
,3
]}

Quer, Josep ^{[1
,2
,3
]}

机构：

[1] Hosp Univ Vall Hebron, Dept Internal Med, Liver Unit, Barcelona 08035, Spain

[2] Univ Autonoma Barcelona, UAB, Bellaterra, Spain

[3] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBERRehd, Madrid, Spain

[4] Banc Sang Teixits, Inst Catala Salut, Barcelona, Spain

来源：

VIROLOGY | 2008年 / 370卷 / 02期

关键词：

HCV-NS3; inhibitor; mutant; resistant; untreated; patient;

D O I：

10.1016/j.virol.2007.10.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：237 / 245

页数：9

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