Development and characterisation of silver-doped bioactive glasscoated sutures for tissue engineering and wound healing applications

被引:243
作者
Blaker, JJ
Nazhat, SN
Boccaccini, AR
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, Ctr Tissue Engn & Regenerat Med, London SW7 2BP, England
[2] Univ London Imperial Coll Sci Technol & Med, Ctr Composite Mat, Ctr Tissue Engn & Regenerat Med, London SW7 2BP, England
[3] UCL, Eastman Dent Inst, Dept Biomat, London WC1X 8LD, England
关键词
suture; bioactive glass; composite; silver; DMA (dynamic mechanical analysis); antibacterial;
D O I
10.1016/j.biomaterials.2003.08.007
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A novel silver-doped bioactive glass powder (AgBG) was used to coat resorbable Vicryl(R) (polyglactin 910) and non-resorbable Mersilk(R) surgical sutures, thereby imparting bioactive, antimicrobial and bactericidal properties to the sutures. Stable and homogeneous coatings on the surface of the sutures were achieved using an optimised aqueous slurry-dipping technique. Dynamic mechanical analysis (DMA) was used to investigate the viscoelastic parameters of storage modulus and tan delta and thermal transitions of the as-received and composite (coated) sutures. The results generally showed that the bioactive glass coating did not affect the dynamic mechanical and thermal properties of the sutures. The in vitro bioactivity of the sutures was tested by immersion in simulated body fluid (SBF). After only 3 days of immersion in SBF, bonelike hydroxyapatite formed on the coated suture surfaces, indicating their enhanced bioactive behaviour. Resorbable sutures with bioactive coatings as fabricated here, in conjunction with 3-D textile technology. may provide attractive materials for producing 3-D scaffolds with controlled porosities for tissue engineering applications. The bactericidal properties imparted by the Ag-containing glass coating open also new opportunities for use of the composite sutures in wound healing and body wall repair. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1319 / 1329
页数:11
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