Functional interaction between opioid and cannabinoid receptors in drug self-administration

被引:279
作者
Navarro, M [1 ]
Carrera, MRA
Fratta, W
Valverde, O
Cossu, G
Fattore, L
Chowen, JA
Gómez, R
del Arco, I
Villanúa, MA
Maldonado, R
Koob, GF
de Fonseca, FR
机构
[1] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Madrid 28223, Spain
[2] Univ Complutense Madrid, Dept Fisiol, Madrid 28223, Spain
[3] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA
[4] Univ Cagliari, Dept Neurosci, I-09124 Sardinia, Italy
[5] Univ Pompeu Fabra, Dept Farmacol, Barcelona 08003, Spain
[6] CSIC, Inst Cajal, E-28002 Madrid, Spain
[7] Fdn Hosp Carlos Haya, Malaga 29010, Spain
关键词
addiction; cannabinoid; drug abuse; opioid; rat; mice; self-administration;
D O I
10.1523/JNEUROSCI.21-14-05344.2001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.
引用
收藏
页码:5344 / 5350
页数:7
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