Cell division and hematopoietic stem cells - Not always exhausting

被引：13

作者：

Walkley, CR

McArthur, GA

Purton, LE

机构：

[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Vic 3002, Australia

[2] Peter MacCallum Canc Ctr, Dept Haematol & Med Oncol, Melbourne, Vic 3002, Australia

[3] Univ Melbourne, St Vincents Hosp, Dept Med, Parkville, Vic 3052, Australia

来源：

CELL CYCLE | 2005年 / 4卷 / 07期

基金：

英国医学研究理事会;

关键词：

cell cycle; hematopoietic stem cell; self-renewal; differentiation; p27Kip1; Mad1;

D O I：

10.4161/cc.4.7.1831

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pluripotent hematopoietic stem cells (HSCs) sustain blood cell production throughout an individual's lifespan through complex processes supported by self-renewal, differentiation, senescence or cell death decisions of the HSCs. These decisions are tightly regulated under homeostatic conditions, allowing both the continuous generation of progenitors and mature cells in addition to the maintenance and replenishment of the HSC pool. Several recent studies have provided insights into some of the key molecular mechanisms regulating these different cell fate decisions. One of the emerging themes of these studies is that of the importance of cell cycle regulators in the maintenance of HSCs.

引用

页码：893 / 896

页数：4

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