Glucuronidation and the UDP-glucuronosyltransferases in health and disease

被引：180

作者：

Wells, PG

Mackenzie, PI

Chowdhury, JR

Guillemette, C

Gregory, PA

Ishii, Y

Hansen, AJ

Kessler, FK

Kim, PM

Chowdhury, NR

Ritter, JK

机构：

[1] Univ Toronto, Fac Pharm, Toronto, ON, Canada

[2] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[3] Flinders Med Ctr, Dept Clin Pharmacol, Adelaide, SA, Australia

[4] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 812, Japan

[5] Yeshiva Univ Albert Einstein Coll Med, Bronx, NY 10461 USA

[6] Univ Laval, Fac Pharm, Quebec City, PQ, Canada

[7] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

DRUG METABOLISM AND DISPOSITION | 2004年 / 32卷 / 03期

关键词：

D O I：

10.1124/dmd.32.3.281

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.

引用

页码：281 / 290

页数：10

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