An elusive receptor is finally caught:: P2Y12, an important drug target in platelets

被引：42

作者：

Barnard, EA ^{[1
]}

Simon, J ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 08期

关键词：

D O I：

10.1016/S0165-6147(00)01759-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite intensive research, the nucleotide P2 receptor that is involved in the aggregation and activation of platelets by ADP has remained elusive. However, now two research groups have independently identified a new platelet receptor of unexpected structure, P2Y(12), that acts with the P2Y(1) receptor to form the site of ADP activation and explains the multiple transduction mechanisms observed in response to ADP in platelets. Recent evidence also suggests that a third component, ATP action on the P2X(1) receptor ion channel, contributes to platelet activation.

引用

页码：388 / 391

页数：4

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