Facile sythesis of dioscin and its analogues

被引：16

作者：

Hou, SJ

Zou, CC

Zhou, L

Lei, PS ^{[1
]}

Yu, DQ

机构：

[1] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

CHEMISTRY LETTERS | 2005年 / 34卷 / 09期

关键词：

D O I：

10.1246/cl.2005.1220

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Three representative spirostanol saponins that have typical structure of the sugar moiety, diosgenyl 2,3-di-O-alpha-(L)-rhamnopyranosyl-beta-(D)-glucopyranoside, diosgenyl 2,4-di-O-alpha-(L)-rhamnopyranosyl- beta-(D)-glucopyranoside (dioscin), and diosgenyl 2,6di-O-alpha-(L)-rhamnopyranosyl- beta-(D)-glucopyranoside, were synthesized in a facile way. An approach to selectively mask the C-3-hydroxyl of diosgenyl 4,6-O-benzylidene beta-(D)-glucopyranoside was described. A procedure using cerium(IV) ammonium nitrate for selective removal of tert-butyldimethylsilyl group while retaining levulinyl group is afforded.

引用

页码：1220 / 1221

页数：2

共 16 条

[1]

Selective deprotection of either alkyl or aryl silyl ethers from aryl, alkyl bis-silyl ethers [J].