Synthesis of a tetrasubstituted bicyclo[2.2.2]octane as a potential inhibitor of influenza virus sialidase

被引：14

作者：

Smith, PW

Trivedi, N

Howes, PD

Sollis, SL

Rahim, G

Bethell, RC

Lynn, S

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Enzyme Med Chem 2, Stevenage SG1 2NY, Herts, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Enzyme Pharmacol, Stevenage SG1 2NY, Herts, England

[3] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Phys Sci, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00033-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel synthesis of the bicycle [2.2.2] octane ring system has been achieved utilising a tandem Henry cyclisation as the key stage. This chemistry has been employed in the synthesis of a potential inhibitor of influenza virus sialidase (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：611 / 614

页数：4

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