Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis

被引：20

作者：

Flores-Borja, Fabian ^{[1
]}

Mauri, Claudia ^{[1
]}

Ehrenstein, Michael R. ^{[1
]}

机构：

[1] UCL, Dept Med, London W1T 4JF, England

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期

关键词：

Regulatory T cell; Rheumatoid arthritis; Therapy;

D O I：

10.1002/eji.200738107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treg play a vital role in the maintenance of tolerance to self antigens, thereby preventing disease through the active suppression of proliferation and pro-inflammatory cytokine production by autoreactive T cells. Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer.

引用

收藏

页码：934 / 937

页数：4

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