Mosquito immune responses against malaria parasites

被引：40

作者：

Blandin, S

Levashina, EA

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] CNRS, Inst Biol Mol & Cellulaire, Unite Propre Rech 9022, F-67084 Strasbourg, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.coi.2003.11.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anopheline mosquitoes are the major vectors of human malaria. Mosquito-parasite interactions are a critical aspect of disease transmission and a potential target for malaria control. Mosquitoes vary in their innate ability to support development of the malaria parasite, but the molecular mechanisms that determine vector competence are poorly understood. This area of research has been revolutionized by recent advances in the mosquito genome characterization and by the development of new tools for functional gene analysis.

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收藏

页码：16 / 20

页数：5

相关论文

共 34 条

[1] The dynamics of interactions between Plasmodium and the mosquito:: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti [J].

Alavi, Y ;

Arai, M ;

Mendoza, J ;

Tufet-Bayona, M ;

Sinha, R ;

Fowler, K ;

Billker, O ;

Franke-Fayard, B ;

Janse, CJ ;

Waters, A ;

Sinden, RE .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2003, 33 (09) :933-943

[2] Mosquito immune responses and malaria transmission: lessons from insect model systems and implications for vertebrate innate immunity and vaccine development [J].

Barillas-Mury, C ;

Wizel, B ;

Han, YS .

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2000, 30 (06) :429-442

[3] Reverse genetics in the mosquito Anopheles gambiae:: targeted disruption of the Defensin gene [J].

Blandin, S ;

Moita, LF ;

Köcher, T ;

Wilm, M ;

Kafatos, FC ;

Levashina, EA .

EMBO REPORTS, 2002, 3 (09) :852-856

[4] Transcripts of the malaria vector Anopheles gambiae that are differentially regulated in the midgut upon exposure to invasive stages of Plasmodium falciparum [J].

Bonnet, S ;

Prévot, G ;

Jacques, JC ;

Boudin, C ;

Bourgouin, C .

CELLULAR MICROBIOLOGY, 2001, 3 (07) :449-458

[5] Immunity-related genes and gene families in Anopheles gambiae [J].

Christophides, GK ;

Zdobnov, E ;

Barillas-Mury, C ;

Birney, E ;

Blandin, S ;

Blass, C ;

Brey, PT ;

Collins, FH ;

Danielli, A ;

Dimopoulos, G ;

Hetru, C ;

Hoa, NT ;

Hoffmann, JA ;

Kanzok, SM ;

Letunic, I ;

Levashina, EA ;

Loukeris, TG ;

Lycett, G ;

Meister, S ;

Michel, K ;

Moita, LF ;

Müller, HM ;

Osta, MA ;

Paskewitz, SM ;

Reichhart, JM ;

Rzhetsky, A ;

Troxler, L ;

Vernick, KD ;

Vlachou, D ;

Volz, J ;

von Mering, C ;

Xu, JN ;

Zheng, LB ;

Bork, P ;

Kafatos, FC .

SCIENCE, 2002, 298 (5591) :159-165

[6] GENETIC SELECTION OF A PLASMODIUM-REFRACTORY STRAIN OF THE MALARIA VECTOR ANOPHELES-GAMBIAE [J].

COLLINS, FH ;

SAKAI, RK ;

VERNICK, KD ;

PASKEWITZ, S ;

SEELEY, DC ;

MILLER, LH ;

COLLINS, WE ;

CAMPBELL, CC ;

GWADZ, RW .

SCIENCE, 1986, 234 (4776) :607-610

[7] Cloning and characterization of four Anopheles gambiae serpin isoforms, differentially induced in the midgut by Plasmodium berghei invasion [J].

Danielli, A ;

Kafatos, FC ;

Loukeris, TG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :4184-4193

[8] SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development [J].

Dessens, JT ;

Sidén-Kiamos, I ;

Mendoza, J ;

Mahairaki, V ;

Khater, E ;

Vlachou, D ;

Xu, XJ ;

Kafatos, FC ;

Louis, C ;

Dimopoulos, G ;

Sinden, RE .

MOLECULAR MICROBIOLOGY, 2003, 49 (02) :319-329

[9]

Dimopoulos G, 2002, CHEM IMMUNOL, V80, P27

[10] Malaria infection of the mosquito Anopheles gambiae activates immune-responsive genes during critical transition stages of the parasite life cycle [J].

Dimopoulos, G ;

Seeley, D ;

Wolf, A ;

Kafatos, FC .

EMBO JOURNAL, 1998, 17 (21) :6115-6123

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