Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940

被引：27

作者：

Huffman, John W. ^{[1
]}

Thompson, Alicia L. S. ^{[1
]}

Wiley, Jenny L. ^{[2
]}

Martin, Billy R. ^{[2
]}

机构：

[1] Clemson Univ, Howard L Hunter Chem Lab, Clemson, SC 29634 USA

[2] Virginia Commonwealth Univ, Coll Med, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 01期

关键词：

CB1; receptor; CB2; nontraditional cannabinoids; 1-deoxy cannabinoids;

D O I：

10.1016/j.bmc.2007.09.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 1-deoxy analogs of CP-47,497 (8 and 13, n = 0-7) and 1-deoxy analogs of CP-55,940 (9, n = 0-7) have been synthesized and their affinities for the cannabinoid CB1 and CB2 receptors have been determined. Although the majority of these compounds exhibit selectivity for the CB2 receptor, none have greater than modest affinity for either receptor. The interactions of these 1-deoxy nontraditional cannabinoids with the CB2 receptor are discussed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：322 / 335

页数：14

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