A possible placental factor for preeclampsia: sFlt-1

被引：21

作者：

Kita, Naoko ^{[1
]}

Mitsushita, Junji ^{[2
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Obstet & Gynecol, Nagano 3908621, Japan

[2] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 07期

关键词：

preeclampsia; sFlt-1; PlGF; VEGF; hypoxia;

D O I：

10.2174/092986708783885309

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.

引用

页码：711 / 715

页数：5

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